By Ole G. Mouritsen, Luis A. Bagatolli
The current publication supplies a multi-disciplinary standpoint at the physics of existence and the actual function performed by means of lipids (fats) and the lipid-bilayer element of mobilephone membranes. The emphasis is at the actual homes of lipid membranes obvious as delicate and molecularly based interfaces. by way of combining and synthesizing insights bought from various fresh experiences, an test is made to elucidate what membrane constitution is and the way it may be quantitatively defined. in addition, it truly is proven how organic functionality mediated by means of membranes is managed by means of lipid membrane constitution and association on size scales starting from the scale of the person molecule, throughout molecular assemblies of proteins and lipid domain names within the variety of nanometers, to the scale of complete cells. purposes of lipids in nanotechnology and biomedicine also are described.
The first variation of the current publication used to be released in 2005 while lipidomics used to be nonetheless a great deal an rising technological know-how and lipids approximately to be famous as being as very important for all times as proteins, sugars, and genes. This considerably increased and revised variation takes into consideration the large quantity of data received during the last decade. moreover, the ebook now contains extra instructional fabric at the biochemistry of lipids and the foundations of lipid self-assembly.
The e-book is geared toward undergraduate scholars and younger learn staff inside physics, chemistry, biochemistry, molecular biology, food, in addition to pharmaceutical and biomedical sciences.
From the studies of the 1st edition:
"This is a hugely fascinating booklet and a excitement to learn. It represents a brand new and perfect pedagogical advent to the sector of lipids and the biophysics of organic membranes. I reckon that physicists and chemists in addition to biologists will take advantage of this method of the sphere and Mouritsen indicates a deep perception into the actual chemistry of lipids." (Göran Lindblom, Chemistry
and Physics of Lipids 2005, vol. a hundred thirty five, web page 105-106)
"The booklet takes the reader on an exhilarating trip in the course of the lipid international, and Mouritsen draws the eye with a full of life sort of writing … . a finished view of the ‘lipid sea’ may be simply completed, gaining the fitting views for envisaging destiny advancements within the nascent box of lipidomics." (Carla Ferreri, ChemBioChem, Vol. 6 (8), 2005)
Read Online or Download LIFE - AS A MATTER OF FAT: Lipids in a Membrane Biophysics Perspective PDF
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Extra info for LIFE - AS A MATTER OF FAT: Lipids in a Membrane Biophysics Perspective
If this can be achieved, the post-genomic era will not only furnish the greatest challenges but also comprise some of the largest opportunities. Biological membranes are outstanding examples of molecular assemblies of extreme complexity whose structure and function cannot be determined from the genome alone and which present some grand challenges to science. Due to the immense importance for life processes and not least the well-being of human beings, the study of biological membranes has for a long time been a central and very active field of research within medicine and biochemistry.
The actual conformation of the molecule will influence its effective size. A conformation refers to the actual spatial arrangements of the atoms of the molecule. In Figs. , very ordered conformations in which all the C–C–C bonds occur in a zigzag arrangement (all-trans). However, temperature effects will lead to rotations, so-called excitations, around the C–C bonds and consequently to more disordered conformations.
It is somewhat paradoxical that the preoccupation with well-defined molecular structure, which has led to so many successes in structural biology, may be the reason why an advance in the understanding of lipid membrane structure, and structurefunction relationships for membranes, has been rather slow. The problem is that if one searches for well-defined structure in membranes in the same way as investigations are made of the structure of genes and proteins, one is going to utterly fail. The reason for this is that membranes are self-assembled molecular aggregates in which subtle elements of structure arise out of a state of substantial disorder, and where entropy consequently plays a major role.