Anemias and Other Red Cell Disorders by Kenneth Bridges, Howard A. Pearson

By Kenneth Bridges, Howard A. Pearson

The 1st entire, but concise, medical advisor to the total spectrum of anemias Anemias and different crimson phone issues is the 1st source to supply a realistic diagnostic/treatment framework for selecting and effectively coping with acute, congenital, and protracted anemias, and different purple blood telephone issues. With its huge scope, easy-to-navigate structure, and ready-to-apply diagnostic and therapy thoughts, this is often the main obtainable - and crucial - consultant to anemias and comparable ailments ever released. gains an entire top-to-bottom assessment of anemias, written with the non-specialist in brain Logical bankruptcy association in accordance with the medical positive factors that suggested the preliminary come across among health care provider and sufferer Discussions of anemias on the topic of physiological stipulations resembling anemia in age and being pregnant, or because of endocrine and metabolic conditions--categories which are often encountered in medical perform yet hardly ever addressed in conventional hematology texts A unified sufferer administration technique in every one regularly formatted bankruptcy Key Diagnostic positive aspects and Key administration concerns tables inside each one bankruptcy useful insights that assist you assessment pathologic fabric to figure out the presence and severity of the disorder assurance of therapy modalities on the vanguard of scientific perform, together with chemotherapy, monoclonal antibodies, and stem and hematopoietic stem telephone transplantation

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Consideration of the overall clinical context of the anemia, however, completes the interpretation of the number. A patient presenting with “mild fatigue and weakness” could on evaluation have a hemoglobin value of 4 g/dL. Another patient who complains of marked fatigue and lethargy might have a hemoglobin value of 10 g/dL. These different presentations provide valuable initial clues in the work-up. The first patient has inveterate anemia. Physiological and behavioral adaptations over time mask the gravity of the condition.

Aplastic anemia is the sine qua non in this category. With other anemias, the bone marrow functions normally while the red cells are lost prematurely. Peptic ulcer disease with bleeding into the gastrointestinal tract can cause this problem. Classification of the anemia as a primary or secondary problem is a key early step in the evaluation. The reticulocyte count is the test that defines this branch point. Table 1-6 provides an overview of this bifurcation with a small number of specific examples.

Splinter hemorrhages of the nail beds raise the possibility that anemia is secondary to underlying bacterial endocarditis. Ocular examination often shows pale retinae in association with severe anemia. Some retinal abnormalities such as the “sea fan” and “salmon patch” defects of sickle cell disease are visible only with indirect ophthalmoscopy. Blue sclerae are common to iron deficiency. Thinning of the scleral membrane highlights the bluish coloration of the underlying epithelium. Icteric sclerae occur with hemolytic anemias of all types.

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