Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia by Andrew Hadley, Peter Soothill

By Andrew Hadley, Peter Soothill

The potent prevention, prognosis, and administration of alloimmune cytopenias has develop into a crew attempt concerning hematologists, obstetricians, pediatricians, immunologists, laboratory technicians, midwives, and learn scientists. This publication has been written through specialists of their respective fields to collect the problems of pathogenesis, epidemiology, prevention, prognosis, and scientific administration. This entire yet available account is widely cross-referenced to stress the hyperlinks among pathogenesis and scientific sequels, among epidemiology and the reason for screening courses, and among analysis and healing intervention.

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Extra info for Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn

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Bailliere’s Clinics in Obstetrics and Gynaecology, 6, 417–38. 68 Mawas F, Wiener E, Ryan G, Soothill PW & Rodeck CH (1994). The expression of IgG Fc receptors on circulating leucocytes in the fetus and new-born. Transfusion Medicine, 4, 25–33. 69 Murphy FJ & Reen DJ (1996). Differential expression of function-related antigens on newborn and adult monocyte subpopulations. Immunology, 89, 587–91. 70 Warmerdam PAM, van der Winkel JGJ, Gosselin EJ & Capel PJA (1990). Molecular basis for a polymorphism of human Fc␥RII (CD32).

Human monocyte interaction with antibody coated platelets. American Journal of Hematology, 17, 225–36. Lucas GF, Hadley AG & Holburn AM (1987). Anti-platelet opsonic activity in alloimmune and autoimmune thrombocytopenia. Clinical Laboratory Haematology, 9, 59–66. McKenzie SE, Taylor SM, Malladi P et al. (1999). The role of the human Fc receptor Fc␥RIIA in the immune clearance of platelets: a transgenic mouse model. Journal of Immunology, 162, 4311–18. Jungi TW, Spycher MO, Nydegger UE & Barandun S (1986).

Thus, every antigen has a unique six-digit number. For example, the third antigen of the Kell system, Kpa, has the number 006003 and the more commonly used alphanumerical symbol, KEL3. Finally, phenotypes are written in the format KEL:Ϫ1,2,Ϫ3,4 (where minus before the number represents absence of the antigen). Genes are written in the format KEL 3 and genotypes are written in the format KEL 1,2/Ϫ1,2. Insufficient genetic information makes it currently impossible for some blood group antigens to be allocated either to a system or to cause the establishment of a new system.

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